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Using the finding of a reduction in
2019-06-28
Using the finding of a 12% reduction in neonatal mortality, Pitt and colleagues show that, even though the reduction in neonatal mortality was relatively modest, the intervention would still be cost-effective. With further statistical modelling they calculate that such an intervention is likely to b
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The distribution of dental treatments and the number
2019-06-28
The distribution of dental treatments and the number of treated teeth within each age group were also analyzed. The 6-years-old group had the lowest mean number of teeth treated by stainless-steel crown (SSC) and the lowest number undergoing pulp therapy (pNorfloxacin hydrochloride and, when compa
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In a study of the atrial pacing preference APP
2019-06-28
In a study of the atrial pacing preference (APP) algorithm, Ogawa et al. [12] randomly programmed pacemakers as APP OFF and APP ON at 3 different settings (8, 16, and 33 cycles). The authors found that the most effective setting differed according to the patient and thus concluded that this therapy
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Introduction Osteosarcoma OS is the most common
2019-06-28
Introduction Osteosarcoma (OS) is the most common type of bone tumor occurred in adolescents and children [1]. OS is highly malignant and accounts for about half of bone sarcomas with high potential of metastasis [2]. Treatment for OS is mainly depended on surgical operation, assisted with chemothe
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br Conflict of interest br Authors
2019-06-28
Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in
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br Introduction Once metastatic breast cancer cells
2019-06-28
Introduction Once metastatic breast cancer nonreceptor tyrosine kinase are in the bone marrow, they hijack signals coming from the normal bone remodelling process and promote bone degradation [1]. Bone degradation is caused by osteoclasts, which have the unique property to dissolve bone mineral a
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This Ca overload activates the forward mode of
2019-06-28
This Ca2+ overload activates the forward mode of the Na+/Ca+ exchanger (NCX), increases the transient inward current (Iti), and induces ventricular arrhythmias due to delayed after depolarizations (DADs). Subtypes of CPVT Several subtypes of CPVT have been reported (Table 1). The most common typ
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An ERP in the ECG has
2019-06-28
An ERP in the ECG has been shown to be familial [187–189]. ERP and ERS have been associated with variants in 7 genes. Consistent with the findings that IK-ATP activation can generate an ERP in canine ventricular wedge preparations, variants in KCNJ8 and ABCC9, responsible for the pore- forming and
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br Conclusion br Limitations br Conflict of interest br
2019-06-28
Conclusion Limitations Conflict of interest Introduction The prevalence of Nalidixic acid failure prevalence is increasing throughout the world. The reasons for this pandemic include the aging populations of both industrialized and developing nations and a growing incidence of obesity, d
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En Introducci n Bases filos ficas del
2019-06-28
En “Introducción. Bases filosóficas del poema” (11-34), Evodio Escalante une los tres hilos de las grandes madejas que considera fundamentales para entender el origen y los alcances de este poema filosófico: Heidegger, Nietzsche y de Gorostiza. La presentación es gradual y va de la mera conexión ane
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br Case report A year
2019-06-27
Case report A 50-year-old female presented with splenomegaly (24 cm) and pancytopenia in Mar. 2014. A bone marrow biopsy revealed hypocellular marrow (orexins of R-COP (Fig. 3). Further 5 cycles of cytotoxic therapy with standard dose R-CEOP (rituximab; cyclophosphamide; epirubicin; vincistine,
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Bisphosphonates are a well established standard of care
2019-06-27
Bisphosphonates are a well-established, standard-of care treatment option to reduce the frequency and severity and time of onset of the skeletal related events (SREs) in patients with bone metastases due to either solid tumours or multiple myeloma [21–33]. From many years, BPs have been incorporated
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SQTS is relatively rare but should be
2019-06-27
SQTS is relatively rare, but should be considered if the QT interval is markedly abbreviated and the ST segment is nearly absent with peaked and symmetrical T waves. Thus far, mutations in 5 different genes have been found, but genetic testing remains investigational because these genes account for
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br Patients and methods br Results
2019-06-27
Patients and methods Results Discussion In the ZOTECT study, ZOL therapy was associated with significantly decreased P1NP and CTX levels within 1 month of initiating treatment (PGANT61 with data from a small trial in patients with newly diagnosed bone metastases from PC, BC, or lung cancer
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Introduction Metastasis to the bone is a common complication
2019-06-27
Introduction Metastasis to the bone is a common complication of breast, lung, prostate, gastrointestinal, haematological, melanoma, and other tumours [1–3]. In many patients with primary breast, prostate and lung primary tumours, bone metastases (BoM) are signs associated with the presence of disse
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