• br Introduction Glucose homeostasis is

  2022-01-29

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β 94 7 is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory hormone

• The role of cell to cell interactions in coordinating the

  2022-01-29

  

  The role of cell-to-cell interactions in coordinating the cells’ behaviour to ensure an appropriate anterior pituitary hormone response is receiving increasing attention. Anterior pituitary DNA Damage DNA Repair Library interact with neighbouring cells through junctional complexes. As their name imp

• There has been conflicting evidence on the possible receptor

  2022-01-28

  

  There has been conflicting evidence on the possible receptor mechanisms that mediate the neuro-immuno-modulatory effects of FAAH substrates. Evidence from in vitro studies indicates that AEA-mediated modulation of TLR4-induced neuroinflammation may be mediated by CB1/CB2 receptor dependent (Correa

• With LML methyl oxo dihydropyridazin yl

  2022-01-28

  

  With LML-134 (1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)piperidin-4-yl 4-cyclobutylpiperazine-1-carboxylate) containing drug-likeness properties (MW 375.47, five HBA, and MLogP 1.88), Novartis presents an additional drug-candidate to treat excessive sleepiness. A phase I clinical study was perform

• Glutathione in reduced form GSH the tripeptide glutamyl

  2022-01-28

  

  Glutathione in reduced form (GSH, the tripeptide, γ-glutamyl cysteinyl glycine) is a non-enzymatic low-molecular-weight antioxidant necessary for the maintenance of a cellular redox state (Noctor et al., 2012). At the stage of the transition from germination to seedling growth the process of cell d

• The compounds f and a e were found to

  2022-01-28

  

  The compounds 8f and 9a–e were found to be potent inhibitors of both isoforms of GSK-3 as characterized by IC50 values in the low nanomolar range. In addition, all of them showed good selectivities against other kinases. Substituents in the ortho- and para-positions of structure 8 and 9 lead to pote

• br Acknowledgments br Introduction Oocyte donation has incre

  2022-01-28

  

  Acknowledgments Introduction Oocyte donation has increasingly been used as an option for infertile women with preserved ovarian function but expected poor outcomes, e.g. low responders to standard ovarian stimulation and women who have experienced repeated implantation failure. Transfer of emb

• PKI-402 br Regulation of Glu transporters The pivotal role

  2022-01-28

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino PKI-402 calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transcriptio

• br Conflict of interest br Funding br

  2022-01-28

  

  Conflict of interest Funding Acknowledgements Introduction to SLC6 transporters The solute carrier (SLC) 6 family of membrane proteins perform the Na+-coupled symport of amino acids and amino Pridinol Methanesulfonate derivatives into cells throughout the body. Disrupting neurotransmitt

• EAAT glutamate uptake is driven by the co

  2022-01-28

  

  EAAT glutamate uptake is driven by the co-transport of three sodium ions and one proton, as well as the counter-transport of one potassium ion (Fig. 1B). This complex stoichiometry frees up enough energy to permit biotin products of glutamate into the cell against a steep concentration gradient. Ad

• The third generation cephalosporin antibiotics can

  2022-01-28

  

  The third-generation cephalosporin DPP4 Activity Fluorometric Assay Kit can cross the blood brain barrier (BBB) [94]. In addition, several studies have shown that CEF can also cross the BBB [95,96] through a facilitated transport process [95]. However, due to the fact that CEF has poor bioavailabil

• br Acknowledgements This work was financed

  2022-01-28

  

  Acknowledgements This work was financed by the projects “Mejora Genética del Almendro” (MINECO-Spain, AGL2017-85042-R), “The molecular mechanisms to break flower bud dormancy in fruit trees” to RS-P within the Villum Young Investigator Program and by the VILLUM Research Center for Plant Plastici

• br Materials and methods br Results br Discussion

  2022-01-27

  

  Materials and methods Results Discussion Our data show that the ghrelin receptor, Ghsr, links energy homeostasis with a form of adult hippocampal plasticity. The presence of Ghsr on mature DG neurons suggest that acyl-ghrelin may modulate NSPCs indirectly, possibly via soluble factors such

• br Conclusion In conclusion rats in this

  2022-01-27

  

  Conclusion In conclusion, rats in this model of HELLP syndrome demonstrated increased placental and circulating FasL and increased placental Fas when compared to NP rats. Administration of an ETA receptor antagonist to HELLP rats tended to decrease circulating FasL and placental Fas, while not a

• 4EGI-1 The Rho family of GTPases is composed of many small

  2022-01-27

  

  The Rho family of GTPases is composed of many small ubiquitous signaling G proteins that bind to guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). They act as switches: when binding to GTP, they are active and associate with a variety of target proteins that regulate intr

15898 records 515/1060 page Previous Next First page 上5页 511512513514515 下5页 Last page