• br Conflict of interest br Authors

  2019-06-28

  

  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

• br Introduction Once metastatic breast cancer cells

  2019-06-28

  

  Introduction Once metastatic breast cancer nonreceptor tyrosine kinase are in the bone marrow, they hijack signals coming from the normal bone remodelling process and promote bone degradation [1]. Bone degradation is caused by osteoclasts, which have the unique property to dissolve bone mineral a

• This Ca overload activates the forward mode of

  2019-06-28

  

  This Ca2+ overload activates the forward mode of the Na+/Ca+ exchanger (NCX), increases the transient inward current (Iti), and induces ventricular arrhythmias due to delayed after depolarizations (DADs). Subtypes of CPVT Several subtypes of CPVT have been reported (Table 1). The most common typ

• An ERP in the ECG has

  2019-06-28

  

  An ERP in the ECG has been shown to be familial [187–189]. ERP and ERS have been associated with variants in 7 genes. Consistent with the findings that IK-ATP activation can generate an ERP in canine ventricular wedge preparations, variants in KCNJ8 and ABCC9, responsible for the pore- forming and

• br Conclusion br Limitations br Conflict of interest br

  2019-06-28

  

  Conclusion Limitations Conflict of interest Introduction The prevalence of Nalidixic acid failure prevalence is increasing throughout the world. The reasons for this pandemic include the aging populations of both industrialized and developing nations and a growing incidence of obesity, d

• En Introducci n Bases filos ficas del

  2019-06-28

  

  En “Introducción. Bases filosóficas del poema” (11-34), Evodio Escalante une los tres hilos de las grandes madejas que considera fundamentales para entender el origen y los alcances de este poema filosófico: Heidegger, Nietzsche y de Gorostiza. La presentación es gradual y va de la mera conexión ane

• br Case report A year

  2019-06-27

  

  Case report A 50-year-old female presented with splenomegaly (24 cm) and pancytopenia in Mar. 2014. A bone marrow biopsy revealed hypocellular marrow (orexins of R-COP (Fig. 3). Further 5 cycles of cytotoxic therapy with standard dose R-CEOP (rituximab; cyclophosphamide; epirubicin; vincistine,

• Bisphosphonates are a well established standard of care

  2019-06-27

  

  Bisphosphonates are a well-established, standard-of care treatment option to reduce the frequency and severity and time of onset of the skeletal related events (SREs) in patients with bone metastases due to either solid tumours or multiple myeloma [21–33]. From many years, BPs have been incorporated

• SQTS is relatively rare but should be

  2019-06-27

  

  SQTS is relatively rare, but should be considered if the QT interval is markedly abbreviated and the ST segment is nearly absent with peaked and symmetrical T waves. Thus far, mutations in 5 different genes have been found, but genetic testing remains investigational because these genes account for

• br Patients and methods br Results

  2019-06-27

  

  Patients and methods Results Discussion In the ZOTECT study, ZOL therapy was associated with significantly decreased P1NP and CTX levels within 1 month of initiating treatment (PGANT61 with data from a small trial in patients with newly diagnosed bone metastases from PC, BC, or lung cancer

• Introduction Metastasis to the bone is a common complication

  2019-06-27

  

  Introduction Metastasis to the bone is a common complication of breast, lung, prostate, gastrointestinal, haematological, melanoma, and other tumours [1–3]. In many patients with primary breast, prostate and lung primary tumours, bone metastases (BoM) are signs associated with the presence of disse

• Sin embargo la Relaci n no fue traducida en forma

  2019-06-27

  

  Sin embargo, la Relación no fue traducida en forma igualmente precisa por Ulloa, que nos devuelve un texto corrompido, lo cual se manifiesta en las transcripciones de los términos en la lengua indígena. Por fortuna, es posible comparar el texto italiano con otras versiones producidas durante la prim

• Vistos por lo tanto desde la ideolog a revolucionaria

  2019-06-27

  

  Vistos, por lo tanto, desde la ideología revolucionaria ascendente, los marginales/campesinos conformaron, más que una presencia ciudadana, en sentido moderno, una especie de sensibilidad motivadora en la que se autorrecreaba una ontología de lo nacional. Esta fuerza fue muy importante en la articul

• In most patients with MCL multi

  2019-06-27

  

  In most patients with MCL, multi-organ involvement with organ damage is seen [2–5,10]. In most cases, the BM is the primary site of disease evolution [13]. However, only a smaller subset of patients with MCL present with circulating MC, and only very few cases present with rapidly increasing numbers

• Case report A previously healthy year old man was referred

  2019-06-27

  

  Case report A previously healthy 37-year-old man was referred to our hospital in September 2015 with fever (between 37 and 38°C) for 10 days and general malaise. There was no history of recent travel, and the patient had no animals in his home. There were no remarkable features in the heart, lungs,

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